BECN1/Beclin1
分类: 最上层  发布时间: 2018-03-20 18:36 

BECN1/Beclin1
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货号: WL02237
抗体名: BECN1/Beclin1 抗体
抗体英文名: BECN1/Beclin1 antibody
浓度: >1mg/ml
应用范围: WB,IHC
宿主:
适应物种: H,M,R
标记物:
克隆性:
保存条件: -20℃
形态: 液体
亚型: IgG
规格: 50μl(>50μg)
本公司所有一抗,50μl(>50μg)现价450元/支,全部现货,均提供20μl免费试用装,详情请点击免费试用
 
产品货号 WL02237
产品名称 BECN1/Beclin1 Antibody
预测分子量 60kDa
别名 ATG6; VPS30; beclin1
浓度 >1 mg/ml
免疫原 合成BECN1/Beclin1多肽
抗体来源
特异性 抗人,小鼠,大鼠
克隆类型 多克隆抗体
产品应用 WB;IHC
成分 亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,NaN3<0.02%
保存条件 -20℃保存
背景资料 Beclin 1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Beclin 1 can complement defects in yeast autophagy caused by loss of Apg6 and can also stimulate autophagy when overexpressed in mammalian cells. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of proteins activated in response to nutrient deprivation and in neurodegenerative conditions . One of the proteins critical to this process is Beclin 1, the mammalian orthologue of the yeast autophagy protein Apg6/Vps30. Mammalian Beclin 1 was originally isolated in a yeast two-hybrid screen for Bcl-2 interacting proteins and has been shown to interact with Bcl-2 and Bcl-xL, but not with Bax or Bak.
 
 
 
 
 
 
 
 


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